A BRCA-Negative Patient With Incidental Serous Tubal Intraepithelial Carcinoma
Kaniz Zehra Abbas, MD, Diana El Neemany, DO, Nicole Pursell, DO, Xiu Sun, MD, Karim El Sahwi, MD
Unit of Gynecologic Oncology (Drs Abbas, El Neemany, Pursell, and El Sahwi) and Department of Pathology (Dr Sun), Meridian Health, Neptune, New Jersey, USA.
Introduction: The incidence of STIC is increasing because of standardization of fallopian tube fimbria examination. We report a case of incidental STIC in a patient being treated for cervical dysplasia. A case report is presented with a review of the literature.
Case Description: This is a 46-year-old BRCA patient who had repeated cervical intraepithelial neoplasia (CIN) type III and underwent robot-assisted total laparoscopic hysterectomy and bilateral salpingectomy, after a subsequent incidental finding of STIC. Laparoscopic surgical staging was completed and 18-month surveillance had been achieved at this writing.
Discussion: Incidental STIC in patients without genetic susceptibility to hereditary breast and ovarian cancer (HBOC) syndrome has been reported. Patients found to have an incidental STIC lesion should be considered for completion of surgical staging and surveillance and should be referred for BRCA1 or -2 mutation testing. A good outcome is likely.
Key Words: Risk reducing salpingectomy, Serous tubal intraepithelial carcinoma.