A Tiny Ovarian Teratoma Leading to a Life-Threatening Condition

Oshri Barel, MD, MHA, Jim Tsaltas, MBBS, Sam Sturrock, BM, BS, Amani Harris, BM, BS, Kim Dobromilsky, BM, BS, BPharm

Gynaecological Endoscopy Unit, Department of Obstetrics and Gynaecology, Monash Health, Bentleigh East, Victoria, Australia (all authors).


Introduction: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe condition that can be life threat- ening. It is occasionally associated with ovarian mature teratomas. Prompt treatment of the syndrome and the associated tumor can result in complete recovery.

Case Description: We present a case of anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis associated with a very small (9-mm) ovarian teratoma. Removal of the teratoma along with immunosuppressive therapy led to full recovery of the patient.

Discussion: This underrecognized paraneoplastic syndrome can be complex and life threatening. Quick removal of the associated tumor allows for a better prognosis. This paper includes a review of the literature.

Key Words: Dermoid, Encephalitis, Limbic, NMDA, Teratoma.

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